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small guide rna sgrna vector  (Addgene inc)


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    Addgene inc small guide rna sgrna vector
    Small Guide Rna Sgrna Vector, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 39 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/small+guide+rna+sgrna+vector/PU6%3A%3Aunc-119_sgRNA+(Plasmid+%2346169)/pmc05846859__mmc1-107-23-27
    Average 93 stars, based on 39 article reviews
    small guide rna sgrna vector - by Bioz Stars, 2026-09
    93/100 stars

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    Image Search Results


    Associations between VMP1 expression and clinicopathological features. A Box diagram of VMP1 gene expression in LGG, GBM, and normal tissues. Violin plot of VMP1 gene expression for grades 2–4 in TCGA ( B ), CGGA ( C ), and GSE16011 ( D ) datasets. The black horizontal line represents the median gene expression level for each grade, and the upper and lower edges in the white box represent the upper and lower quartiles in the data set. The violin graph can also reflect the data density, where a more concentrated data set yields a broader graph. E Immunohistochemical analysis of VMP1 protein expression for different grades. Box diagram of VMP1 gene expression with respect to different clinical pathological features, including the IDH status ( F ), 1p/19q codeletion ( G ), TERT status ( H ), and MGMT promoter status ( I ). P-values were determined using Wilcoxon tests (* P < 0.05; *** P < 0.001; **** P < 0.0001)

    Journal: Journal of Neuroinflammation

    Article Title: VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy

    doi: 10.1186/s12974-021-02213-z

    Figure Lengend Snippet: Associations between VMP1 expression and clinicopathological features. A Box diagram of VMP1 gene expression in LGG, GBM, and normal tissues. Violin plot of VMP1 gene expression for grades 2–4 in TCGA ( B ), CGGA ( C ), and GSE16011 ( D ) datasets. The black horizontal line represents the median gene expression level for each grade, and the upper and lower edges in the white box represent the upper and lower quartiles in the data set. The violin graph can also reflect the data density, where a more concentrated data set yields a broader graph. E Immunohistochemical analysis of VMP1 protein expression for different grades. Box diagram of VMP1 gene expression with respect to different clinical pathological features, including the IDH status ( F ), 1p/19q codeletion ( G ), TERT status ( H ), and MGMT promoter status ( I ). P-values were determined using Wilcoxon tests (* P < 0.05; *** P < 0.001; **** P < 0.0001)

    Article Snippet: A CRISPR-Cas9 small guide RNA (sgRNA) lentiviral vector targeting human VMP1 was obtained from Genechem Co., Ltd. (Shanghai, China).

    Techniques: Expressing, Immunohistochemical staining

    Prognostic value of VMP1 expression in glioma. A Patient status distributions in the high and low VMP1 expression groups. Each dot shows the patient status ranked by increasing expression. The X -axis shows the number of patients and the Y -axis shows the survival time. B Mortality rates in the high and low VMP1 expression groups. Kaplan–Meier overall survival curves for patients assigned to each VMP1 expression group in three datasets: CGGA ( C ), TCGA ( D ), and cohort ( E )

    Journal: Journal of Neuroinflammation

    Article Title: VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy

    doi: 10.1186/s12974-021-02213-z

    Figure Lengend Snippet: Prognostic value of VMP1 expression in glioma. A Patient status distributions in the high and low VMP1 expression groups. Each dot shows the patient status ranked by increasing expression. The X -axis shows the number of patients and the Y -axis shows the survival time. B Mortality rates in the high and low VMP1 expression groups. Kaplan–Meier overall survival curves for patients assigned to each VMP1 expression group in three datasets: CGGA ( C ), TCGA ( D ), and cohort ( E )

    Article Snippet: A CRISPR-Cas9 small guide RNA (sgRNA) lentiviral vector targeting human VMP1 was obtained from Genechem Co., Ltd. (Shanghai, China).

    Techniques: Expressing

    VMP1 expression serves as an independent prognostic factor. A Univariate Cox analyses revealed significant prognostic parameters. B Multivariate Cox analyses identified independent prognostic factors. C , D The results of univariate Cox analyses and multivariate Cox analyses were further validated in TCGA

    Journal: Journal of Neuroinflammation

    Article Title: VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy

    doi: 10.1186/s12974-021-02213-z

    Figure Lengend Snippet: VMP1 expression serves as an independent prognostic factor. A Univariate Cox analyses revealed significant prognostic parameters. B Multivariate Cox analyses identified independent prognostic factors. C , D The results of univariate Cox analyses and multivariate Cox analyses were further validated in TCGA

    Article Snippet: A CRISPR-Cas9 small guide RNA (sgRNA) lentiviral vector targeting human VMP1 was obtained from Genechem Co., Ltd. (Shanghai, China).

    Techniques: Expressing

    VMP1 knockout inhibits cell proliferation and induces cell death. A A KEGG signaling pathway enrichment analysis of differentially expressed genes (DEGs) between the VMP1 high and low groups. The intensity of the color represents the − log10 adjusted P-value, and dot sizes show the number of DEGs enriched in the corresponding pathway. B GSEA revealed that genes in the VMP1 high group were enriched in cancer hallmark pathways. Gene sets with normalized enrichment score (NES) > 1 and nominal P -value (NOM P-val) < 0.05 were considered significant. C Schematic diagram illustrating the CRISPR-Cas9-mediated VMP1 editing system and western blotting to confirm the decrease in VMP1 expression. D Cell growth in the wild-type group, VMP1 sgRNA1 group (VMP1 KO1), and VMP1 sgRNA2 group (VMP1 KO2). E , F Results of a clonogenic assay. Red circles represent the clones being counted. G , H Visualization of DNA replication by EdU incorporation. Cell nuclei stained in red represent DNA replication. I Annexin V-FITC and PI staining to determine the percentage of apoptotic cells. J Cell cycle analysis. P-values were determined via Student’s t -test (* P < 0.05; ** P < 0.01; *** P < 0.001)

    Journal: Journal of Neuroinflammation

    Article Title: VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy

    doi: 10.1186/s12974-021-02213-z

    Figure Lengend Snippet: VMP1 knockout inhibits cell proliferation and induces cell death. A A KEGG signaling pathway enrichment analysis of differentially expressed genes (DEGs) between the VMP1 high and low groups. The intensity of the color represents the − log10 adjusted P-value, and dot sizes show the number of DEGs enriched in the corresponding pathway. B GSEA revealed that genes in the VMP1 high group were enriched in cancer hallmark pathways. Gene sets with normalized enrichment score (NES) > 1 and nominal P -value (NOM P-val) < 0.05 were considered significant. C Schematic diagram illustrating the CRISPR-Cas9-mediated VMP1 editing system and western blotting to confirm the decrease in VMP1 expression. D Cell growth in the wild-type group, VMP1 sgRNA1 group (VMP1 KO1), and VMP1 sgRNA2 group (VMP1 KO2). E , F Results of a clonogenic assay. Red circles represent the clones being counted. G , H Visualization of DNA replication by EdU incorporation. Cell nuclei stained in red represent DNA replication. I Annexin V-FITC and PI staining to determine the percentage of apoptotic cells. J Cell cycle analysis. P-values were determined via Student’s t -test (* P < 0.05; ** P < 0.01; *** P < 0.001)

    Article Snippet: A CRISPR-Cas9 small guide RNA (sgRNA) lentiviral vector targeting human VMP1 was obtained from Genechem Co., Ltd. (Shanghai, China).

    Techniques: Knock-Out, CRISPR, Western Blot, Expressing, Clonogenic Assay, Clone Assay, Staining, Cell Cycle Assay

    VMP1 depletion inhibits the progression of autophagic flux. A GSEA showed that genes in the VMP1 high group were enriched in pathways related to the regulation of autophagy and lysosomes. Correlation between VMP1 expression and autophagy-related genes, including ATG4A ( B ), ATG4C ( C ), ATG5 ( D ), ATG7 ( E ), ATG9B ( F ), ATG10 ( G ), and ATG12 ( H ). I , J RFP-GFP-LC3B dual-reporter assay showing the accumulation of autolysosomes. RFP-positive and GFP-negative dots indicate autolysosomes. K TEM microphotographs showing the ultrastructure of cells. Red arrows indicate endogenous autolysosomes

    Journal: Journal of Neuroinflammation

    Article Title: VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy

    doi: 10.1186/s12974-021-02213-z

    Figure Lengend Snippet: VMP1 depletion inhibits the progression of autophagic flux. A GSEA showed that genes in the VMP1 high group were enriched in pathways related to the regulation of autophagy and lysosomes. Correlation between VMP1 expression and autophagy-related genes, including ATG4A ( B ), ATG4C ( C ), ATG5 ( D ), ATG7 ( E ), ATG9B ( F ), ATG10 ( G ), and ATG12 ( H ). I , J RFP-GFP-LC3B dual-reporter assay showing the accumulation of autolysosomes. RFP-positive and GFP-negative dots indicate autolysosomes. K TEM microphotographs showing the ultrastructure of cells. Red arrows indicate endogenous autolysosomes

    Article Snippet: A CRISPR-Cas9 small guide RNA (sgRNA) lentiviral vector targeting human VMP1 was obtained from Genechem Co., Ltd. (Shanghai, China).

    Techniques: Expressing, Reporter Assay

    VMP1 depletion sensitizes glioma to radiotherapy. A , B Annexin V-FITC and PI staining using flow cytometry. C , D Quantification of the formation of phosphorylated (S139) γ-H2AX foci, as determined by immunofluorescence. E Kaplan–Meier overall survival curves for patients in the VMP1 high and low groups who received radiotherapy. P-values were determined by Student’s t -tests (* P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001)

    Journal: Journal of Neuroinflammation

    Article Title: VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy

    doi: 10.1186/s12974-021-02213-z

    Figure Lengend Snippet: VMP1 depletion sensitizes glioma to radiotherapy. A , B Annexin V-FITC and PI staining using flow cytometry. C , D Quantification of the formation of phosphorylated (S139) γ-H2AX foci, as determined by immunofluorescence. E Kaplan–Meier overall survival curves for patients in the VMP1 high and low groups who received radiotherapy. P-values were determined by Student’s t -tests (* P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001)

    Article Snippet: A CRISPR-Cas9 small guide RNA (sgRNA) lentiviral vector targeting human VMP1 was obtained from Genechem Co., Ltd. (Shanghai, China).

    Techniques: Staining, Flow Cytometry, Immunofluorescence

    VMP1 depletion sensitizes glioma to chemotherapy. A Annexin V-FITC and PI staining using flow cytometry. B Kaplan–Meier overall survival curves for patients in the VMP1 high and low groups who received chemotherapy. P-values were determined by Student’s t -tests (* P < 0.05; ** P < 0.01; *** P < 0.001)

    Journal: Journal of Neuroinflammation

    Article Title: VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy

    doi: 10.1186/s12974-021-02213-z

    Figure Lengend Snippet: VMP1 depletion sensitizes glioma to chemotherapy. A Annexin V-FITC and PI staining using flow cytometry. B Kaplan–Meier overall survival curves for patients in the VMP1 high and low groups who received chemotherapy. P-values were determined by Student’s t -tests (* P < 0.05; ** P < 0.01; *** P < 0.001)

    Article Snippet: A CRISPR-Cas9 small guide RNA (sgRNA) lentiviral vector targeting human VMP1 was obtained from Genechem Co., Ltd. (Shanghai, China).

    Techniques: Staining, Flow Cytometry

    Nomogram development and performance. A Construction of a nomogram model to predict 1-, 3-, and 5-year OS based on VMP1 expression and clinicopathological parameters. Calibration plots of the nomogram for 3-year ( B ) and 5-year ( C ) survival. The x -axis shows the nomogram-predicted probability and the y -axis represents the observed probability. D ROC curve showing the predictive efficiency of the nomogram for 1-, 3-, and 5-year OS

    Journal: Journal of Neuroinflammation

    Article Title: VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy

    doi: 10.1186/s12974-021-02213-z

    Figure Lengend Snippet: Nomogram development and performance. A Construction of a nomogram model to predict 1-, 3-, and 5-year OS based on VMP1 expression and clinicopathological parameters. Calibration plots of the nomogram for 3-year ( B ) and 5-year ( C ) survival. The x -axis shows the nomogram-predicted probability and the y -axis represents the observed probability. D ROC curve showing the predictive efficiency of the nomogram for 1-, 3-, and 5-year OS

    Article Snippet: A CRISPR-Cas9 small guide RNA (sgRNA) lentiviral vector targeting human VMP1 was obtained from Genechem Co., Ltd. (Shanghai, China).

    Techniques: Expressing